![]() Biopsy growth in hIL2-NOG mice was negatively associated with survival in patients previously treated with PD-1 checkpoint blockade. IL2 appears to activate T-cell immunity in the biopsies to block tumor growth. RESULTS: Biopsies grew readily in NOG mice but growth was heterogeneous in hIL2-NOG mice. Tumor growth was monitored, and comparisons were made with clinical data, sequencing data, and current in silico predictive tools. PATIENTS AND METHODS: Melanoma biopsies contained in a retrospective biobank were transplanted into NOG mice or NOG mice expressing interleukin 2 (hIL2-NOG mice). Here we assessed the value of immune-PDX mouse models for predicting responses to anti-PD-1 checkpoint inhibitor therapy in patients. BACKGROUND: The mouse strains usually used to generate patient-derived xenografts (PDXs) are immunocompromised, rendering them unsuitable for immunotherapy studies. ![]()
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